jackman/biol125-lectures
1
0
Fork 0
Code Issues Pull Requests Releases Wiki Activity

electric motion fin

Browse Source
This commit is contained in:
ackman678
2021-12-06 09:11:52 -08:00
parent a75e1d2ea8
commit 97f76cfe87
6 changed files with 143 additions and 97 deletions
Download Patch File Download Diff File Expand all files Collapse all files

24
basal-ganglia.md
View File

@@ -243,8 +243,12 @@ Note:
<figure><figcaption>sign shows normal effect (excite or inhibit) at that synapse</figcaption><img src="figs/Neuroscience5e-Fig-18.04-2R_cc3e2e7.jpg" height="400px"><figcaption>Neuroscience 5e Fig. 18.4</figcaption></figure>
*Remember that caudate/putamen medium spiny neurons are usually not active*
<div style="font-size:0.5em;">
The GABAergic projection caudate/putamen medium spiny neurons are usually pretty quiet: they have a **low baseline spike rate.**
The GABAergic projection pallidus/reticulata neurons have a **high baseline spike rate.**
</div>
Note:
@@ -280,10 +284,16 @@ Count spikes surrounding eye movement period, y axis is count (histogram), x axi
---
## Disinhibition through the direct pathway increases activity in upper motor neurons
## Direct pathway
<figure><figcaption class="big">Direct pathway: ctx --> putamen --> GPi --> VA/VL --> ctx</figcaption><img src="figs/2016-11-21-basal-ganglia-circuits_86a5b8d.svg" height="400px"><figcaption>J. Ackman [CC0](https://creativecommons.org/share-your-work/public-domain/cc0/)</figcaption></figure>
<figure><figcaption class="big">Direct pathway: ctx --> putamen --> GPi --> VA/VL --> ctx</figcaption><img src="figs/2016-11-21-basal-ganglia-circuits_86a5b8d.svg" height="400px"><figcaption>
JA [CC0](https://creativecommons.org/share-your-work/public-domain/cc0/)</figcaption></figure>
<div style="font-size:0.6em;">
Disinhibition through the **direct pathway** increases activity in upper motor neurons
</div>
Note:
@@ -306,7 +316,9 @@ Note:
## Indirect pathway
<figure><figcaption class="big">Indirect pathway: ctx --> putamen --> GPe --> STN --> GPi --> VA/VL --> ctx</figcaption><img src="figs/2016-11-21-basal-ganglia-circuits_86a5b8d.svg" height="400px"><figcaption>JA [CC0](https://creativecommons.org/share-your-work/public-domain/cc0/)</figcaption></figure>
<figure><figcaption class="big">Indirect pathway: ctx --> putamen --> GPe --> STN --> GPi --> VA/VL --> ctx</figcaption><img src="figs/2016-11-21-basal-ganglia-circuits_86a5b8d.svg" height="400px"><figcaption>
JA [CC0](https://creativecommons.org/share-your-work/public-domain/cc0/)</figcaption></figure>
Note:
@@ -434,7 +446,9 @@ Note:
<figure><figcaption class="big">
Defects in the subthalamic nucleus contralateral to the involuntary movements.
Reduced indirect pathway function.
</figcaption><img src="figs/2016-11-21-basal-ganglia-circuits-disease_4509692.svg" height="400px"><figcaption>JA [CC0](https://creativecommons.org/share-your-work/public-domain/cc0/)</figcaption></figure>
</figcaption><img src="figs/2016-11-21-basal-ganglia-circuits-disease_4509692.svg" height="400px"><figcaption>
JA [CC0](https://creativecommons.org/share-your-work/public-domain/cc0/)</figcaption></figure>
Note: