diff --git a/2016-10-16-lecture09.md b/2016-10-16-lecture09.md
index b468ef6..8cae6ff 100644
--- a/2016-10-16-lecture09.md
+++ b/2016-10-16-lecture09.md
@@ -25,25 +25,9 @@ What types of cell-cell communication underly signaling? The answer is familiar
 
 ---
 
-## Endocrine signaling
+## Synaptic, paracrine, and endocrine signaling
 
-<div><img src="tmp/img002_91bc4ab.jpg" height="100px"><figcaption></figcaption></div>
-
-Note:
-
----
-
-## Paracrine signaling
-
-<div><img src="tmp/img003_d18bced.jpg" height="100px"><figcaption></figcaption></div>
-
-Note:
-
----
-
-## Signaling by membrane proteins
-
-<div><img src="tmp/img005_64aadb9.jpg" height="100px"><figcaption></figcaption></div>
+<figure><img src="figs/Neuroscience5e-Fig-07.01-2R_copy_eef31ad.jpg" height="300px"><figcaption>Neuroscience 5e Fig. 7.1</figcaption></figure>
 
 Note:
 
@@ -61,7 +45,6 @@ Note:
 Note:
 
 
-
 ---
 
 ## Signal amplification
@@ -69,7 +52,8 @@ Note:
 * results in a tremendous increase in the potency of the initial signal
 * permits precise control of cell behavior
 
-<div><img src="tmp/Neuroscience5e-Fig-07.02-0_bed2f4c.jpg" height="100px"><figcaption></figcaption></div>
+<figure><img src="figs/Neuroscience5e-Fig-07.02-0_87ce39a.jpg" height="300px"><figcaption>Neuroscience 5e Fig. 7.2</figcaption></figure>
+
 Note:
 
 
@@ -77,11 +61,16 @@ Note:
 
 ## Types of receptors
 
+<div style="font-size:0.8em;">
+<div></div>
+
 * Ligand gated ion channels (channel linked receptors/ionotropic receptors)– e.g. nAChR, AMPA receptors
 * Enzyme linked receptors– typically have extracellular binding site for signals. Has intracellular domain with catalytic activity regulated by signal. Most are protein kinases that phosphorylate intracellular proteins. e.g. tyrosine kinase
 * G-protein coupled receptors–  7-transmembrane spanning receptors that signal through trimeric G-proteins intracellularly. The proteins can alter the function of many downstream proteins.  e.g. muscarinic AChR, metabotropic glutamate receptors
 * Intracellular receptors– activated by cell permeant or lipophilic signaling molecules like steroid hormones. Signal binds directly to an intracellular protein which then activates transcription
 
+</div>
+
 Note:
 
 
@@ -90,9 +79,8 @@ Note:
 
 ## Categories of cellular receptors
 
-Neuroscience 5e 7.4
+<figure><img src="figs/Neuroscience5e-Fig-07.04-0R_1_631f6c3.png" height="400px"><figcaption>Neuroscience 5e Fig. 7.4</figcaption></figure>
 
-<div><img src="tmp/Neuroscience5e-Fig-07.04-0R_f4a3cfb.jpg" height="100px"><figcaption></figcaption></div>
 
 Note:
 
@@ -104,7 +92,8 @@ For enzyme linked receptors the signal binds extracellularly, which activates th
 
 ## Categories of cellular receptors
 
-Neuroscience 5e 7.4
+<figure><img src="figs/Neuroscience5e-Fig-07.04-0R_2_c164eb9.png" height="400px"><figcaption>Neuroscience 5e Fig. 7.4</figcaption></figure>
+
 
 Note:
 
@@ -122,7 +111,7 @@ For intracellular receptors, the signaling molecule passes through lipid membran
 * Two types of G-proteins:
     * Heterotrimeric G- proteins, composed of an α,β, γ subunits. Multiple members of each class. α subunit binds and hydrolyses GTP
     * Small G-proteins– monomeric GTPases (e.g. ras)
-* Active when bound to GTP, inactive when bound to GDP.  
+* Active when bound to GTP, inactive when bound to GDP
 
 Note:
 
@@ -148,12 +137,12 @@ Rate of GTP hydrolysis is important property of G-protein mediated signaling and
 
 ## Types of GTP-binding proteins
 
-<div><img src="tmp/Neuroscience5e-Fig-07.05-0_79ccd4d.jpg" height="100px"><figcaption></figcaption></div>
+<figure><img src="figs/Neuroscience5e-Fig-07.05-0_ae701d1.jpg" height="400px"><figcaption>Neuroscience 5e Fig. 7.5</figcaption></figure>
+
 
 Note:
 
 
-
 ---
 
 ## Trimeric G-protein signaling
@@ -164,7 +153,8 @@ Note:
 * Dissociates complex and activates 
 * α and βγ subunits
 
-<div><img src="tmp/image_ed5b758.png" height="100px"><figcaption></figcaption></div>
+<figure><img src="figs/MolBiolCell-4e-Fig-15-28_bb1fb6c.png" height="300px"><figcaption>Molecular Biology of the Cell 4e Fig. 15.28</figcaption></figure>
+
 
 Note:
 
@@ -190,11 +180,11 @@ Effector enzymes for activated G-proteins include adenylyl cyclase, guanylyl cyc
 
 ## Effector pathways associated with G-protein coupled receptors
 
-<div><img src="tmp/Neuroscience5e-Fig-07.06-0_0622e51.jpg" height="100px"><figcaption></figcaption></div>
+<figure><img src="figs/Neuroscience5e-Fig-07.06-0_c5e7495.jpg" height="400px"><figcaption>Neuroscience 5e Fig. 7.6</figcaption></figure>
+
 
 Note:
 
-
 There are many types of alpha, beta, and gamma g-protein subunits allowing a specific and diverse range of downstream responses. 
 
 This shows three examples of different heterotrimeric g proteins bound to 3 types of receptors with 3 different cellular responses. 
@@ -221,7 +211,8 @@ One target of calcium is calmodulin, a calcium binding protein abundant in the c
 
 ## Proteins involved in delivering and removing calcium to the cytoplasm
 
-<div><img src="tmp/Neuroscience5e-Fig-07.07-2R_e19682f.jpg" height="100px"><figcaption></figcaption></div>
+<figure><img src="figs/Neuroscience5e-Fig-07.07-2R_copy_3559450.jpg" height="300px"><figcaption>Neuroscience 5e Fig. 7.7</figcaption></figure>
+
 
 Note:
 
@@ -244,41 +235,37 @@ Another one intracellular releasing channel is the ryanodine receptor. These are
 
 ## Calcium activates calmodulin
 
-<div><img src="tmp/image1_ee185b5.png" height="100px"><figcaption></figcaption></div>
+<figure><img src="figs/MolBiolCell-4e-Fig-15-40_8aee979.png" height="400px"><figcaption>Molecular Biology of the Cell 4e Fig. 15.40</figcaption></figure>
 
 Note:
 
 
-
 ---
 
-## Title Text
+## Calcium second messaging video summary
 
-[http://courses.pbsci.ucsc.edu/mcdb/bio125/Animation07-02CalciumasaSecondMessenger.mov](http://courses.pbsci.ucsc.edu/mcdb/bio125/Animation07-02CalciumasaSecondMessenger.mov)
-
-<div><img src="tmp/posterImage_aefb8c9.png" height="100px"><figcaption></figcaption></div>
+<div><video height=400px controls src="figs/Animation07-02CalciumasaSecondMessenger.mp4"></video><figcaption>Neuroscience 5e Animation 7.2</figcaption></div>
 
 Note:
 
 
-
 ---
 
 ## Second messengers: cyclic nucleotides
 
 * cAMP and cGMP– derivatives of ATP and GTP. Made by adenylyl cyclase and guanylyl cyclase
-* Bind to many targets– cAMP to protein kinase A; cGMP to protein kinase G
+* Bind to many targets– cAMP to protein kinase A, cGMP to protein kinase G
 * Phosphodiesterases cleave cAMP and cGMP to inactivate them
 
 Note:
 
 
-
 ---
 
 ## cAMP formation and destruction
 
-<div><img src="tmp/image2_cd109cb.png" height="100px"><figcaption></figcaption></div>
+<figure><img src="figs/MolBiolCell-4e-Fig-15-31_f75639e.png" height="300px"><figcaption>Molecular Biology of the Cell 4e Fig. 15.31</figcaption></figure>
+
 
 Note:
 
@@ -300,18 +287,20 @@ Note:
 
 ## Diacylglycerol and IP3
 
-<div><img src="tmp/image3_ff001a8.png" height="100px"><figcaption></figcaption></div>
+<figure><img src="figs/MolBiolCell-4e-Fig-15-35_466d627.png" height="400px"><figcaption>Molecular Biology of the Cell 4e Fig. 15.35</figcaption></figure>
+
 
 Note:
 
-Phosphatidylinositol 4,5-bisphosphate: PIP2,
+Phosphatidylinositol 4,5-bisphosphate: PIP2
 
 
 ---
 
 ## Neuronal second messengers
 
-<div><img src="tmp/Neuroscience5e-Fig-07.07-1R_075e716.jpg" height="100px"><figcaption></figcaption></div>
+<figure><img src="figs/Neuroscience5e-Fig-07.07-1R_copy_20bca17.jpg" height="400px"><figcaption>Neuroscience 5e Fig. 7.7</figcaption></figure>
+
 
 Note:
 
@@ -322,36 +311,16 @@ This table summarizes neuronal second messengers, their sources, targets, and in
 
 ## Second messenger life cycles
 
-cyclic nucleotides
+<div><figcaption class="big">cyclic nucleotides</figcaption><img src="figs/Neuroscience5e-Fig-07.07-3R_copy_b4b6941.jpg" height="200px"><figcaption>Neuroscience 5e Fig. 7.7</figcaption></div>
 
-lipid signals
+<div><figcaption class="big">lipid signals</figcaption><img src="figs/Neuroscience5e-Fig-07.07-4R_copy_724e472.jpg" height="200px"><figcaption>Neuroscience 5e Fig. 7.7</figcaption></div>
 
-Neuroscience 5e 7.7
-
-<div><img src="tmp/Neuroscience5e-Fig-07.07-3R_3c25bf5.jpg" height="100px"><figcaption></figcaption></div>
-
-<div><img src="tmp/Neuroscience5e-Fig-07.07-4R_d7c0fa2.jpg" height="100px"><figcaption></figcaption></div>
 
 Note:
 
 And this depicts the mechanisms involved in production and degradation or removal of cyclic nucleotides and DAG and IP3.
 
 
----
-
-## Second messenger life cycles
-
-cyclic nucleotides
-
-lipid signals
-
-gas signals
-
-<div><img src="tmp/PN08073_69fa3e7.jpg" height="100px"><figcaption></figcaption></div>
-
-Note:
-
-
 ---
 
 ## 2nd messengers target protein kinases and phosphatases
@@ -377,7 +346,8 @@ Protein substrates of kinases and phosphataes include enzymes, neurotransmitter
 
 ## Regulation of cellular proteins by phosphorylation
 
-<div><img src="tmp/Neuroscience5e-Fig-07.08-0_3d12fd1.jpg" height="100px"><figcaption></figcaption></div>
+<figure><img src="figs/Neuroscience5e-Fig-07.08-0_fe35b8f.jpg" height="300px"><figcaption>Neuroscience 5e Fig. 7.8</figcaption></figure>
+
 
 Note:
 
@@ -399,19 +369,10 @@ Note:
 
 ## Mechanism of activation of protein kinases
 
-binding of cAMP to regulatory
+<figure style="margin:15px 0;"><figcaption class="big">binding of cAMP to regulatory subunits free up the catalytic subunits</figcaption><img src="figs/Neuroscience5e-Fig-07.09-1R_copy_9cfd048.jpg" height="100px"><figcaption>Neuroscience 5e Fig. 7.9</figcaption></figure>
+<figure style="margin:15px 0;"><figcaption class="big">binding of calmodulin opens up protein to activate catalytic domain</figcaption><img src="figs/Neuroscience5e-Fig-07.09-2R_copy_d343a3d.jpg" height="100px"><figcaption>Neuroscience 5e Fig. 7.9</figcaption></figure>
+<figure style="margin:15px 0;"><figcaption class="big">DAG causes PKC to change its localization which leads it to be active</figcaption><img src="figs/Neuroscience5e-Fig-07.09-3R_copy_e5e5f7e.jpg" height="100px"><figcaption>Neuroscience 5e Fig. 7.9</figcaption></figure>
 
-subunits free up the catalytic subunits
-
-binding of calmodulin opens up
-
-protein to activate catalytic domain
-
-DAG causes PKC to change its
-
-localization which leads it to be active
-
-<div><img src="tmp/Neuroscience5e-Fig-07.09-0_630932e.jpg" height="100px"><figcaption></figcaption></div>
 
 Note:
 
@@ -421,12 +382,12 @@ Note:
 
 ## Protein kinase A activation
 
-<div><img src="tmp/image4_632667b.png" height="100px"><figcaption></figcaption></div>
+<figure><img src="figs/MolBiolCell-4e-Fig-15-32_607bbe8.png" height="300px"><figcaption>Molecular Biology of the Cell 4e Fig. 15.32</figcaption></figure>
+
 
 Note:
 
 
-
 ---
 
 ## Other kinases
@@ -449,7 +410,7 @@ Mitogen activated protein kinases (MAP kinases)
 
 ## MAP kinase cascade
 
-<div><img src="tmp/image5_ad676a6.png" height="100px"><figcaption></figcaption></div>
+<figure><img src="figs/MolBiolCell-4e-Fig-15-56_d3306b4.png" height="300px"><figcaption>Molecular Biology of the Cell 4e Fig. 15-56</figcaption></figure>
 
 Note:
 
@@ -474,7 +435,7 @@ CREB is an important nuclear signal
 
 ## Steps involved in transcription of DNA to RNA
 
-<div><img src="tmp/Neuroscience5e-Fig-07.10-0_4962198.jpg" height="100px"><figcaption></figcaption></div>
+<figure><img src="figs/Neuroscience5e-Fig-07.10-0_9a72f7c.jpg" height="500px"><figcaption>Neuroscience 5e Fig. 7.10</figcaption></figure>
 
 Note:
 
@@ -485,10 +446,8 @@ uas: upstream activator sequence
 >upstream activating sequence or upstream activation sequence (UAS) is a cis-acting regulatory sequence. It is distinct from the promoter and increases the expression of a neighbouring gene.
 
 -upstream from minimal promoter TATA box, binding site for transactivators
-
 -a cis acting regulatory sequence (like IRES)
 
-
 ---
 
 ## CREB
@@ -503,54 +462,27 @@ Note:
 
 ## Transcriptional regulation by CREB
 
-<div><img src="tmp/Neuroscience5e-Fig-07.11-0_2eaee54.jpg" height="100px"><figcaption></figcaption></div>
+<figure><img src="figs/Neuroscience5e-Fig-07.11-0_22d362e.jpg" height="400px"><figcaption>Neuroscience 5e Fig. 7.11</figcaption></figure>
+
 
 Note:
 
 
 ---
 
-## Title Text
+## Chemical signaling mechanisms video summary
 
-[http://courses.pbsci.ucsc.edu/mcdb/bio125/Animation07-01ChemicalSignalingMechanismsandAmplification.mov](http://courses.pbsci.ucsc.edu/mcdb/bio125/Animation07-01ChemicalSignalingMechanismsandAmplification.mov)
-
-<div><img src="tmp/posterImage1_eb3dd6e.png" height="100px"><figcaption></figcaption></div>
+<div><video height=400px controls src="figs/Animation07-01ChemicalSignalingMechanismsandAmplification.mp4"></video><figcaption>Neuroscience 5e Animation 5.2</figcaption></div>
 
 Note:
 
 
----
-
-## Nurturing defects in CREB mutant mice
-
-WT
-
-mutant
-
-<div><img src="tmp/image6_f94d96e.png" height="100px"><figcaption></figcaption></div>
-
-Note:
-
-
----
-
-## How does NGF promote axon outgrowth
-
--NGF
-
-+NGF
-
-<div><img src="tmp/image7_7dc0be2.png" height="100px"><figcaption></figcaption></div>
-
-Note:
-
-
-
 ---
 
 ## Mechanism of action of NGF
 
-<div><img src="tmp/Neuroscience5e-Fig-07.12-0_968df2f.jpg" height="100px"><figcaption></figcaption></div>
+<figure><img src="figs/Neuroscience5e-Fig-07.12-0_1bc4863.jpg" height="400px"><figcaption>Neuroscience 5e Fig. 7.12</figcaption></figure>
+
 
 Note:
 
@@ -561,12 +493,18 @@ nerve growth factor, binds to tyrosine kinase receptor (TrkA) leading to…
 
 ## Signaling at cerebellar parallel fiber synapses
 
+<div style="font-size:0.7em;width:400px;">
+<div></div>
+
 * Glutamate released from presynaptic cell binds ionotropic and metabotropic glutamate receptors
 * AMPA receptor opens and excites cell
 * mGluR receptor activates a signal transduction pathway that feeds back and decreases AMPA receptor activity
 * Called long term depression because now the same stimulus will lead to less depolarization than before (weakened synapse)
 
-<div><img src="tmp/Neuroscience5e-Fig-07.13-0_843784b.jpg" height="100px"><figcaption></figcaption></div>
+</div>
+
+<div style="margin:0 15px;"><img src="figs/Neuroscience5e-Fig-07.13-0_0ff2e8b.jpg" height="300px"><figcaption>Neuroscience 5e Fig. 7.13</figcaption></div>
+
 
 Note:
 
@@ -586,6 +524,9 @@ likely from phosphorylation of AMPA receptors by PKC and their elimination from
 
 ## Regulation of tyrosine hydroxylase by protein phosphorylation
 
+<div style="font-size:0.7em;">
+<div></div>
+
 * AP invades axon terminal
 * Voltage-gated Ca²⁺ channels open
 * Intracellular Ca²⁺ does two things: 
@@ -597,7 +538,10 @@ likely from phosphorylation of AMPA receptors by PKC and their elimination from
 * Increase in transmitter release
 * Increase in post-synaptic response
 
-<div><img src="tmp/Neuroscience5e-Fig-07.14-0_5f1370f.jpg" height="100px"><figcaption></figcaption></div>
+</div>
+
+<div style="margin:0 15px;"><img src="figs/Neuroscience5e-Fig-07.14-0_6a79350.jpg" height="400px"><figcaption>Neuroscience 5e Fig. 7.14</figcaption></div>
+
 
 Note: