From 6f86c18e3de62173622a3a0546e2b9417b211743 Mon Sep 17 00:00:00 2001 From: ackman678 Date: Wed, 4 Sep 2013 11:12:24 -0400 Subject: [PATCH] cat files and rm extras from the 'parts' branch with .index mmd file --- wholeBrain_main.md | 37 +++++++++++++++++++++++++++++++++++++ 1 file changed, 37 insertions(+) create mode 100644 wholeBrain_main.md diff --git a/wholeBrain_main.md b/wholeBrain_main.md new file mode 100644 index 0000000..e06a895 --- /dev/null +++ b/wholeBrain_main.md @@ -0,0 +1,37 @@ +Author: James B. Ackman +Date: 2012-12-31 12:30:49 +Date Modified: 2013-09-04 10:54:02 +Tags: paper, draft, manuscript, literature, research, retinal waves, Spontaneous Activity, development + +# Structured population activity across developing neocortex + +# Abstract + +The cerebral cortex exhibits spontaneous and sensory evoked patterns of activity during fetal and postnatal development that are crucial for the activity-dependent formation and refinement of circuits. Knowing the source and flow of these activity patterns locally and globally is crucial to understanding self-organization in the developing brain. Here we describe a system for imaging patterns of activity throughout the developing neocortex at the 'mesoscopic' level of resolution in transgenic mice expressing the genetic calcium indicator GCaMP3. Ongoing activity in the neonatal cerebral cortex was characterized by discrete and repetitively active domains measuring 100s of microns in diameter. This technique offers an unprecedented ability to study functional connectivity within and between the cerebral hemispheres at a scope and scale which bridges the microscopic or macroscopic resolutions offered by traditional neurophysiology and neuroimaging (fMRI) based recordings and will provide a practical means to assess cortical connectivity with high spatial resolution in pathophysiological models for autism, epilepsy, and schizophrenia. + + + +# Introduction + +- Activity and development +- Neural activity, drugs, and birth defects + - epilepsy + - autism +- What is the activity? + - instructive or permissive? + - EEG slow oscillations not detectable until P10 in rodent. + - slice work + - leinekukel and khazipov work + - ucla konnerth imaging work + - human occipital cortex and my retinal wave paper + - is the activity completely random? Or Is it organized in space and time, and at what scale? + - the little that we know is from work in second postnatal week, not earlier, olavarria work, interneuon migration, synaptic formation, and anatomical studies indicates significant development decisions are being made in first postnatal week + +# Results + +<<[wholeBrain_results-ongoing_activity.txt] + +<<[wholeBrain_results-state_dependence.txt] + +<<[wholeBrain_results-hemisphere_corr.txt] +