## Ongoing activity in the neonatal mouse cerebral cortex is characterized by discrete domains ## * Cortical column (mini/meso/super columns) history (20th century anatomists). * Column physiology-- Hubel and Wiesel. Rodent V1? * Developmental studies-- fetal monkey ODCs. * Rodent barrels (early anatomical emergence from TC input, functional/physiological emergence?). * What is known about columns/domains in secondary/association/non-primary sensory representations? Rest of rodent S1 (non-barrel cortex?). * Calcium domains of Yuste, Science 1992 paper. * Other slice calcium recordings, patch/gap junctions. In vivo physiology? (Not too many multisite electrode recordings in cortex, spatial resolution issue). * Calcium imaging-- Konnerth 'waves' in Ent cortex. For visual cortex, domains activity in extrastriate cortex (Ackman Nature 2012). But S1-- Golshani work in later postnatal-- but activity not obeying domains in barrel cortex-- problem with spatial sampling in the xy and the z for this study? Domains: ![](../figures/Screen_Shot_2013-03-29_at_12.06.25_PM_crop.png) Domain overlay: ![](../figures/Screen_Shot_2013-05-14_at_4.11.51_PM_crop.png) Domain stats: key | value | unit --- | --- | --- xmean | 388.6234 | µm ymean | 394.9717 | µm zmean | 0.63622 | s xmax | 3178 | µm ymax | 2383.5 | µm zmax | 14.6 | s xmin | 11.35 | µm ymin | 22.7 | µm zmin | 0.2 | s 2.8683 domains/sec ![](file:///Volumes/Vega/Users/ackman/Data/2photon/120518i/120518_07_connComponents_BkgndSubtr60px-20130327-163111domains20130402-151440.png) Temporal correlation of activity between the hemispheres: ![](../figures/Screen_Shot_2013-04-30_at_3.02.20_PM.png) ![](../figures/Screen_Shot_2013-04-08_at_8.47.19_AM.png)