jackman/wholeBrain
1
0
Fork 0
Code Issues Pull Requests Releases Wiki Activity

Work on intro. Redid some of figures with .eps graphics

Browse Source
This commit is contained in:
ackman678
2013-09-11 16:09:40 -04:00
parent 76434731f6
commit c360fe5106
2 changed files with 4 additions and 5 deletions
Download Patch File Download Diff File Expand all files Collapse all files

BIN
figure1.png
View File

Binary file not shown.
Side by Side Swipe Overlay

Before

Width:  |  Height:  |  Size: 268 KiB

After

Width:  |  Height:  |  Size: 281 KiB

9
wholeBrain_main.md
View File

@@ -17,8 +17,7 @@ The cerebral cortex exhibits spontaneous and sensory evoked patterns of activity
<!--- This should be one paragraph. Some of this intro material could be combined with intro or concl sentences in abstract for a Nature letter (should be referenced and up to 300 words; 200 words preferred) --->
Brain development requires neural activity and calcium dynamics for establishing proper circuit structure and function. The importance of neural activity in the prenatal and neonatal period can be easily recognized in children exposed to chemical agents affecting neurotransmission during the fetal period that result in severe brain malformations, epilepsy, and mental retardation. Indeed, embryonic limb movements in species ranging from chick to human are thought to be initiated by spontaneous motor neuron activity in the spinal cord and has been recognized in chick to human and is thought to be crucial for activity-dependent development of motor synapses [Schoenberg:2003] [Marder,Lichtmann]. However it is only recently that we have begun to appreciate the underlying patterns of persistent neural activity that in fact exist in the developing brain in vivo. For example, sensori-motor feedback associated with spontaneous movement generated by spinal motor neurons triggers synchronized 'spindle-burst' potentials among cells in somatosensory cortex [Yang:2009][Khazipov:2004a] before the start of locomotion and tactile behavior. Correlated bursts of activity occur in the developing rat hippocampus in vivo [#Leinekugel:2002] [Mohns&Blumberg]. Spontaneous retinal waves drive patterned activation of circuits throughout immature visual system before the onset of vision [#Ackman:2012] [Hanganu,Colonnese?]. Slow activity transients occur in the human occipital cortex before birth [#Vanhatalo:2005][#Tolonen:2007]. However to understand the informational capacity of neural activty in the developing brain, the structural dynamics of persistent activity must be understood.
Brain development requires neural activity and calcium dynamics for establishing proper circuit structure and function. The importance of neural activity in the prenatal and neonatal period can be easily recognized in children exposed to chemical agents affecting neurotransmission during the fetal period that result in severe brain malformations, epilepsy, and mental retardation. Indeed, embryonic limb movements in species ranging from chick to human are thought to be initiated by spontaneous motor neuron activity in the spinal cord and has been recognized in chick to human and is thought to be crucial for activity-dependent development of motor synapses [Schoenberg:2003] [Marder,Lichtmann]. However it is only recently that we have begun to appreciate the underlying patterns of persistent neural activity that in fact exist in the developing brain in vivo. For example, sensori-motor feedback associated with spontaneous movement generated by spinal motor neurons triggers synchronized 'spindle-burst' potentials among cells in somatosensory cortex [Yang:2009][Khazipov:2004a] before the start of locomotion and tactile behavior. Correlated bursts of activity occur in the developing rat hippocampus in vivo [#Leinekugel:2002] [Mohns&Blumberg]. Spontaneous retinal waves drive patterned activation of circuits throughout immature visual system before the onset of vision [#Ackman:2012] [Hanganu,Colonnese?]. Furthermore, prenatal EEG recordings have demonstrated spindle burst oscillations and slow activity transients in the human infant somatosensory and occipital cortices before birth [#Vanhatalo:2005][#Tolonen:2007]. However, a comprehensive account of the structural dynamics of persistent activity throughout the developing isocortex in vivo has not been undertaken.
- Neural activity, drugs, and birth defects
@@ -149,8 +148,8 @@ hemisphere active fraction traces: Screen_Shot_2013-04-08_at_8.47.19_AM.png
### Cortical activity and motor activity is periodic
hemi auto & xcorr:
Screen_Shot_2013-04-08_at_2.31.33_PM.png
Screen_Shot_2013-04-08_at_2.34.50_PM.png
Screen_Shot_2013-04-08_at_2.31.33_PM.png | 120518_07_connComponents_BkgndSubtr-60px_noWatershed-20130327-151022activeFraction20130408-143100.eps
Screen_Shot_2013-04-08_at_2.34.50_PM.png | 120518_07_connComponents_BkgndSubtr-60px_noWatershed-20130327-151022activeFraction20130408-151655.eps
Moving average signals color coded at diff lags: Screen_Shot_2013-05-02_at_10.53.40_AM.png
### Cortical activity is correlated with the motor signal
@@ -173,7 +172,7 @@ Screen_Shot_2013-04-19_at_8.30.27_AM_fr759.png
Screen_Shot_2013-04-19_at_8.30.51_AM_fr373.png
Screen_Shot_2013-04-19_at_8.38.54_AM_fr177.png
activefraction hemis AP & ML all: ![](../figures/Screen_Shot_2013-04-23_at_8.45.18_AM.png)
activefraction hemis AP & ML all: ![](../figures/Screen_Shot_2013-04-23_at_8.45.18_AM.png) | 120518_07_connComponents_BkgndSubtr-60px_noWatershed-20130327-151022_d2ractiveFractionPixelLocaCorr20130423-094506.eps
activefraction hemis AP & ML segment: ![](../figures/Screen_Shot_2013-04-23_at_8.46.27_AM.png)
activefraction hemis AP & ML segment: ![](../figures/Screen_Shot_2013-04-23_at_8.51.55_AM.png)
scatterplot ML Screen_Shot_2013-04-22_at_4.29.28_PM.png